REFERENCES / ON THE RECORD
The CJC-1295 studies cited across this digest
Every quantitative claim on this site maps to one of these. Pharmacokinetics, mechanism, the GHRH-analog class, and the regulatory and analytical record.
How to read this CJC-1295 reference list
These are the sources behind the CJC-1295 digest. The core human pharmacokinetic findings come from Teichman 2006 [3] and Ionescu/Frohman 2006 [1]; the albumin-bioconjugate origin from Jette 2005 [2]; the once-daily GHRH-knockout growth result from Alba 2006 [4]; the serum-proteome biomarkers from Sackmann-Sala 2009 [5]; and the class synthesis from the 2025 Nature Reviews Endocrinology review [14]. The GHRH-GHRP synergy and secretagogue-pulsatility supporting work is listed below them. Each entry carries a DOI or PubMed link for verification.
The list is deliberately weighted toward primary literature: peer-reviewed pharmacokinetic and mechanistic studies, a review in a high-impact endocrinology journal, and the analytical-chemistry paper that identified CJC-1295 in a seized preparation [6]. Where a finding on this site is quantitative — a half-life, a fold-change, a dose, a duration — it traces to one of these entries by its bracketed number. Where the site marks an absence (no long-term safety trial, no combination efficacy trial), that absence is a statement about this same body of literature, not an oversight in the list.
- Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006;91(12):4792-4797. ↗
- Jette L, Leger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146(7):3052-3058. ↗
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. ↗
- Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. ↗
- Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009;19(6):471-477. ↗
- Henninge J, Pepaj M, Hullstein I, Hemmersbach P. Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation. Drug Test Anal. 2010;2(11-12):647-650. ↗
- Greater efficacy of episodic than continuous growth hormone-releasing hormone (GHRH) administration on GH release. J Clin Endocrinol Metab. 1996;81(3). ↗
- Determinants of GH-releasing hormone and GH-releasing peptide synergy in men. Am J Physiol Endocrinol Metab. 2009. ↗
- Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced GH secretion. Endocrinology. 2002. ↗
- Differential pulsatile secretagogue control of GH secretion in healthy men. Am J Physiol Regul Integr Comp Physiol. 2013. ↗
- Agonistic analogs of growth hormone releasing hormone (GHRH) promote wound healing. Oncotarget. 2016. ↗
- GHRH expression plasmid improves osteoporosis and skin damage in aged mice. Growth Horm IGF Res. 2021. ↗
- Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity. J Clin Endocrinol Metab. 2011. ↗
- Granata R, Leone S, Zhang X, Gesmundo I, et al. Growth hormone-releasing hormone and its analogues in health and disease. Nat Rev Endocrinol. 2025;21(3):180-195. ↗
- Neuroendocrine circuit for sleep-dependent growth hormone release. Cell. 2025. ↗